![]() ![]() at this age after these mild challenges is actually quite exciting to us and indicates just how early in the disease process these kinds of cognitive changes may be occurring.” “Given these mice were young, otherwise healthy. Initial experiments demonstrated that APP/PSEN1 mice treated with kainic acid exhibited reduced LTP in comparison with other groups, and this was associated with impaired memory retention when performing complex tasks. An experimental protocol was then described, in which wild-type or APP/PSEN1 mice (a mouse model of AD) were repeatedly treated with low doses of kainic acid (an analog of glutamate that induces excitatory postsynaptic potentials) and then assessed for EEG activity and LTP, as well as learning and memory task performance. Although AD mouse models differ from human disease in many respects, the presence of epileptiform activity and EEG changes may be a particularly useful phenotype as they are found in many of the widely studied models. Harrison’s lab is currently focused on the role of diet and environmental factors on glutamatergic excitotoxicity, and she introduced evidence linking hyperexcitability, epilepsy (including sub-clinical epileptiform activity), and seizures with cognitive decline in AD. “To me, the really encouraging thing about Alzheimer’s research is that there is so much we can do in our lives to prevent the cognitive decline, or at least slow its onset, even in the face of pathology.”ĭr. These factors may in turn work via underlying pathological mechanisms such as vascular and metabolic pathways, neuroinflammation, oxidative damage, or neurotransmitter changes. This leads to one of the fundamental questions of AD research – how does the underlying basic pathology lead to cognitive decline? A number of possible factors were described, including nutrition, exercise, general health, sleep, education, and environmental toxins. that patients experience in relation to the pathology within the brain.”Ĭlinical data were presented, illustrating the lack of consistent correlation between amyloid neuropathology and cognitive impairment, however, in contrast, clear associations between amyloid deposition and behavior have been observed in mouse models of AD. One of the interesting and in fact really hopeful facets of Alzheimer’s is that there is a huge difference in the clinical manifestation. Harrison began this webinar with an introduction to the epidemiology of AD and its defining pathology, including a brief discussion of the recent Aducanumab approval and the beta amyloid hypothesis. ![]() If you need assistance locating a specific grade or packaging, call 001- 4041878 / 4123999 or by email Chemical section is organized alphabetically by Chemical name.Dr. With our wide-range selection of products and our nationwide distribution network, we will deliver the product you need on time. Somatco provides Comprehensive Solution for your chemical needs. SOMATCO is a leading firm in the field of Laboratory, Scientific, Medical, Laboratory Chemicals & Hospital Equipments. SOMATCO Supplies Oxygen Concentrators, Oxygen Cylinders, Nebulizers, Humidifiers, Microscopes, Laboratory Boiling Glasswares, Laboratory Blown & pressed Glasswares, Laboratory Bottles, Volumetric Glasswares, Laboratory apparatus, Laboratory Coats, Hospital Electric Beds, Hospital Manual Beds, Dental Unit, Ovens, Incubators, Centrifuges, Balances, Thermometers, Shakers, Skeleton Models, Digital BP Meters, Mercury BP Meters, Wheel Chairs, Stethoscopes, Chemicals, Stirrers, Stirring Motors, Suction Aspirators, Digital Autoclaves, Amplitron Thermal Cycler, Opthalmoscopes, Oscilloscopes, Otoscopes, Oxygen Regulators, Ph meters, Projectors, Radioactive Source Kit, Refrigerators.
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